RESEARCH FOCUS
VACCINES
Key Projects:
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Development of DelNS1 live attenuated vaccine system for influenza and respiratory viral diseases, and as an immune enhancer for cancer antigens
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Improvement of injectable vaccines by intradermal vaccination with topical adjuvant
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Improvement of injectable vaccines by intramuscular vaccination with novel systemic adjuvant
Programme Leaders:
Professor Honglin CHEN (The University of Hong Kong)
Professor Kelvin Kai-Wang TO (The University of Hong Kong)
Key Research Staff:
Professor Dongyan JIN (The University of Hong Kong)
Dr Anna Jinxia ZHANG (The University of Hong Kong)
External Collaborators:
Professor Xiao-Ning XU (Imperial College London)
Professor Ning-Shao XIA (Xiamen University)
BI-SPECIFIC NEUTRALIZING ANTIBODY PLATFORM FOR VIRAL PATHOGENS
Key Projects:
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Engineer bnAbs and bi-bnAbs with improved breadth and potency for protection against multisubtype HIV-1 strains or against respiratory viruses
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Synergistic effect of bnAb and bi-bnAb against a large panel of genetically divergent pseudotype viruses and primary isolates in vitro and in vivo
Programme Leader:
Professor Zhiwei CHEN (The University of Hong Kong)
Key Research Staff:
Professor Honglin CHEN (The University of Hong Kong)
External Collaborators:
Professor David D. HO (Columbia University)
Professor Linqi ZHANG (Tsinghua University)
Professor Tongqing ZHOU (NIH Vaccine Research Center)
Antivirals Targeting Host Factors
Key Projects:
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Development of broad-spectrum antiviral agents targeting the virus-induced metabolic reprogramming
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Targeting the cell fate pathways as novel antiviral strategies
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Discovery of antivirals targeting host factors that are essential for SARS-CoV-2 replication
Programme Leader:
Dr Kin-Hang KOK (The University of Hong Kong)
Key Research Staff:
Dr Jasper Fuk-Woo CHAN (The University of Hong Kong)
Dr Shuofeng YUAN (The University of Hong Kong)
Dr Hin CHU (The University of Hong Kong)
Dr Philip Man-Lung YEUNG (The University of Hong Kong)
External Collaborators:
Professor Stanley Perlman (University of Iowa)
Antivirals Targeting Viral Factors
Key Projects:
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Antiviral agents targeting structural proteins of viruses
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Development of broad spectrum antivirals by evaluating defective interfering genes and antiviral peptides
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Rational design and synthesis of a defective interfering virus for anti-influenza therapy / Flu A DI viruses and coronaviruses
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Establishing human and animal organoids for virus studies
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Nasal protein vaccine booster for Influenza and COVID-19
Programme Leader:
Dr Jasper Fuk-Woo CHAN (The University of Hong Kong)
Key Research Staff:
Dr Richard Yi-Tsun KAO (The University of Hong Kong)
Dr Kin-Hang KOK (The University of Hong Kong)
Dr Hanjun ZHAO (The University of Hong Kong)
Dr Jane Jie ZHOU (The University of Hong Kong)
Dr Philip Man-Lung YEUNG (The University of Hong Kong)
External Collaborators:
Professor Shibo Jiang (Fudan University)
Professor Hans Clevers (F. Hoffmann-La Roche Ltd)
Professor Shuai Xia (Fudan University)
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CONTACT US
E-mail: admin@cvvt.hk
Tel: 3910 3688
Fax: 3753 2284
Address:
1. Laboratory: Unit 208-213, 2/F, Building 15W, Hong Kong Science Park, Pak Shek Kok, N.T.
2. Office: Unit 313-316, 3/F,
Building 17W, Hong Kong Science Park, Pak Shek Kok, N.T.